2021

 

IGF2 Mediates Resistance to Isoform-Selective-Inhibitors of the PI3K in HPV Positive Head and Neck Cancer.

Badarni M, Prasad M, Golden A, Bhattacharya B, Levin L, Yegodayev KM, Dimitstein O, Joshua BZ, Cohen L, Khrameeva E, Kong D, Porgador A, Braiman A, Grandis JR, Rotblat B, Elkabets M.Cancers (Basel). 2021 May 7;13(9):2250. doi: 10.3390/cancers13092250.PMID: 34067117 Free PMC article.

BKM120 sensitizes glioblastoma to the PARP inhibitor rucaparib by suppressing homologous recombination repair.

Zhang S, Peng X, Li X, Liu H, Zhao B, Elkabets M, Liu Y, Wang W, Wang R, Zhong Y, Kong D.Cell Death Dis. 2021 May 26;12(6):546. doi: 10.1038/s41419-021-03805-6.PMID: 34039959 Free PMC article.

José Baselga M.D., Ph.D. (1959-2021) leading cancer researcher and oncologist.

Elkabets M, Blandino G.J Exp Clin Cancer Res. 2021 May 7;40(1):156. doi: 10.1186/s13046-021-01966-y.PMID: 33962670 Free PMC article. No abstract available.

KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix.

Kim JK, Marco MR, Choi SH, Qu X, Chen CT, Elkabets M, Fairchild L, Chow O, Barriga FM, Dow LE, O'Rourke K, Szeglin B, Yarilin D, Fujisawa S, Manova-Todorova K, Paty PB, Shia J, Leslie C, Joshua Smith J, Lowe S, Pelossof R, Sanchez-Vega F, Garcia-Aguilar J.Mol Oncol. 2021 Apr 4. doi: 10.1002/1878-0261.12960. Online ahead of print.PMID: 33817986 Free article.

The 4-NQO mouse model: An update on a well-established in vivo model of oral carcinogenesis.

Bouaoud J, De Souza G, Darido C, Tortereau A, Elkabets M, Bertolus C, Saintigny P.Methods Cell Biol. 2021;163:197-229. doi: 10.1016/bs.mcb.2020.09.004. Epub 2020 Nov 12.PMID: 33785166

Synthetic promoters to induce immune-effectors into the tumor microenvironment.

Greenshpan Y, Sharabi O, Ottolenghi A, Cahana A, Kundu K, M Yegodayev K, Elkabets M, Gazit R, Porgador A.Commun Biol. 2021 Jan 29;4(1):143. doi: 10.1038/s42003-021-01664-7.PMID: 33514819 Free PMC article.

EGFR overexpression increases radiotherapy response in HPV-positive head and neck cancer through inhibition of DNA damage repair and HPV E6 downregulation.

Alsahafi EN, Thavaraj S, Sarvestani N, Novoplansky O, Elkabets M, Ayaz B, Tavassoli M, Legends MF.Cancer Lett. 2021 Feb 1;498:80-97. doi: 10.1016/j.canlet.2020.10.035. Epub 2020 Oct 31.PMID: 33137407

2020

CDK 4/6 Inhibition Overcomes Acquired and Inherent Resistance to PI3Kα Inhibition in Pre-Clinical Models of Head and Neck Squamous Cell Carcinoma.

Remer E, Badarni M, Hikri E, Dayan A, Levi L, Popovtzer A, Iraqi M, Porgador A, Joshua BZ, Bachar G, Elkabets M, Scaltriti M, Mizrachi A.J Clin Med. 2020 Oct 7;9(10):3214. doi: 10.3390/jcm9103214.PMID: 33036331 Free PMC article.

 

TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors.

Cocco E, Lee JE, Kannan S, Schram AM, Won HH, Shifman S, Kulick A, Baldino L, Toska E, Arruabarrena-Aristorena A, Kittane S, Wu F, Cai Y, Arena S, Mussolin B, Kannan R, Vasan N, Gorelick AN, Berger MF, Novoplansky O, Jagadeeshan S, Liao Y, Rix U, Misale S, Taylor BS, Bardelli A, Hechtman JF, Hyman DM, Elkabets M, de Stanchina E, Verma CS, Ventura A, Drilon A, Scaltriti M.Cancer Discov. 2021 Jan;11(1):126-141. doi: 10.1158/2159-8290.CD-20-0571. Epub 2020 Oct 1.PMID: 33004339 Free PMC article.

Surface roughness-induced absorption acts as an ovarian cancer cells growth sensor-monitor.

Katiyi A, Zorea J, Halstuch A, Elkabets M, Karabchevsky A.Biosens Bioelectron. 2020 Aug 1;161:112240. doi: 10.1016/j.bios.2020.112240. Epub 2020 Apr 25.PMID: 32365013

TGF-Beta-Activated Cancer-Associated Fibroblasts Limit Cetuximab Efficacy in Preclinical Models of Head and Neck Cancer.

Yegodayev KM, Novoplansky O, Golden A, Prasad M, Levin L, Jagadeeshan S, Zorea J, Dimitstein O, Joshua BZ, Cohen L, Khrameeva E, Elkabets M.Cancers (Basel). 2020 Feb 3;12(2):339. doi: 10.3390/cancers12020339.PMID: 32028632 Free PMC article.

Probing antibody surface density and analyte antigen incubation time as dominant parameters influencing the antibody-antigen recognition events of a non-faradaic and diffusion-restricted electrochemical immunosensor.

Zorea J, Shukla RP, Elkabets M, Ben-Yoav H.Anal Bioanal Chem. 2020 Mar;412(7):1709-1717. doi: 10.1007/s00216-020-02417-x. Epub 2020 Jan 29.PMID: 31996962 Free PMC article.

In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System.

Prasad M, Jagadeeshan S, Scaltriti M, Allon I, Elkabets M.J Vis Exp. 2020 Jan 9;(155). doi: 10.3791/60410.PMID: 31984965

Potential oncogenic roles of mutant-p53-derived exosomes in the tumor-host interaction of head and neck cancers.

Azulay EE, Cooks T, Elkabets M.Cancer Immunol Immunother. 2020 Feb;69(2):285-292. doi: 10.1007/s00262-019-02450-5. Epub 2020 Jan 3.PMID: 31897662 Review.

2019

Adaptive Responses to Monotherapy in Head and Neck Cancer: Interventions for Rationale-Based Therapeutic Combinations.

Jagadeeshan S, Prasad M, Ortiz-Cuaran S, Gregoire V, Saintigny P, Elkabets M.Trends Cancer. 2019 Jun;5(6):365-390. doi: 10.1016/j.trecan.2019.04.004. Epub 2019 May 28.PMID: 31208698 Review.

Inhibition of the NKp44-PCNA Immune Checkpoint Using a mAb to PCNA.

Kundu K, Ghosh S, Sarkar R, Edri A, Brusilovsky M, Gershoni-Yahalom O, Yossef R, Shemesh A, Soria JC, Lazar V, Joshua BZ, Campbell KS, Elkabets M, Porgador A.Cancer Immunol Res. 2019 Jul;7(7):1120-1134. doi: 10.1158/2326-6066.CIR-19-0023. Epub 2019 Jun 4.PMID: 31164357 Free PMC article.

c-Met as a new marker of cellular senescence.

Boichuck M, Zorea J, Elkabets M, Wolfson M, Fraifeld VE.Aging (Albany NY). 2019 May 13;11(9):2889-2897. doi: 10.18632/aging.101961.PMID: 31085799 Free PMC article.

The long noncoding RNA TP73-AS1 promotes tumorigenicity of medulloblastoma cells.

Varon M, Levy T, Mazor G, Ben David H, Marciano R, Krelin Y, Prasad M, Elkabets M, Pauck D, Ahmadov U, Picard D, Qin N, Borkhardt A, Reifenberger G, Leprivier G, Remke M, Rotblat B.Int J Cancer. 2019 Dec 15;145(12):3402-3413. doi: 10.1002/ijc.32400. Epub 2019 Jun 12.PMID: 31081944

Repression of AXL expression by AP-1/JNK blockage overcomes resistance to PI3Ka therapy.

Badarni M, Prasad M, Balaban N, Zorea J, Yegodayev KM, Joshua BZ, Dinur AB, Grénman R, Rotblat B, Cohen L, Elkabets M.JCI Insight. 2019 Mar 12;5(8):e125341. doi: 10.1172/jci.insight.125341.PMID: 30860495 Free PMC article.

Tumor Tissue Explant Culture of Patient-Derived Xenograft as Potential Prioritization Tool for Targeted Therapy.

Ghosh S, Prasad M, Kundu K, Cohen L, Yegodayev KM, Zorea J, Joshua BZ, Lasry B, Dimitstein O, Bahat-Dinur A, Mizrachi A, Lazar V, Elkabets M, Porgador A.Front Oncol. 2019 Jan 22;9:17. doi: 10.3389/fonc.2019.00017. eCollection 2019.PMID: 30723707 Free PMC article.

High-Throughput Screening Identified Compounds Sensitizing Tumor Cells to Glucose Starvation in Culture and VEGF Inhibitors In Vivo.

Marciano R, Prasad M, Ievy T, Tzadok S, Leprivier G, Elkabets M, Rotblat B.Cancers (Basel). 2019 Jan 30;11(2):156. doi: 10.3390/cancers11020156.PMID: 30704052 Free PMC article.

MET activation confers resistance to cetuximab, and prevents HER2 and HER3 upregulation in head and neck cancer.

Novoplansky O, Fury M, Prasad M, Yegodayev K, Zorea J, Cohen L, Pelossof R, Cohen L, Katabi N, Cecchi F, Joshua BZ, Popovtzer A, Baselga J, Scaltriti M, Elkabets M.Int J Cancer. 2019 Aug 1;145(3):748-762. doi: 10.1002/ijc.32170. Epub 2019 Feb 11.PMID: 30694565 Free PMC article.

Genomic Landscape of Pancreatic Adenocarcinoma in Younger versus Older Patients: Does Age Matter?

Ben-Aharon I, Elkabets M, Pelossof R, Yu KH, Iacubuzio-Donahue CA, Leach SD, Lowery MA, Goodman KA, O'Reilly EM.Clin Cancer Res. 2019 Apr 1;25(7):2185-2193. doi: 10.1158/1078-0432.CCR-18-3042. Epub 2019 Jan 7.PMID: 30617137 Free PMC article.

2018

IGF1R upregulation confers resistance to isoform-specific inhibitors of PI3K in PIK3CA-driven ovarian cancer.

Zorea J, Prasad M, Cohen L, Li N, Schefzik R, Ghosh S, Rotblat B, Brors B, Elkabets M.Cell Death Dis. 2018 Sep 20;9(10):944. doi: 10.1038/s41419-018-1025-8.PMID: 30237504 Free PMC article.

Methods to Study the Role of Progranulin in the Tumor Microenvironment.

Elkabets M, Brook S.Methods Mol Biol. 2018;1806:155-176. doi: 10.1007/978-1-4939-8559-3_12.PMID: 29956276

Enhanced ZnR/GPR39 Activity in Breast Cancer, an Alternative Trigger of Signaling Leading to Cell Growth.

Ventura-Bixenshpaner H, Asraf H, Chakraborty M, Elkabets M, Sekler I, Taylor KM, Hershfinkel M.Sci Rep. 2018 May 25;8(1):8119. doi: 10.1038/s41598-018-26459-5.PMID: 29802348 Free PMC article.

2017

PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D.

Toska E, Osmanbeyoglu HU, Castel P, Chan C, Hendrickson RC, Elkabets M, Dickler MN, Scaltriti M, Leslie CS, Armstrong SA, Baselga J.Science. 2017 Mar 24;355(6331):1324-1330. doi: 10.1126/science.aah6893.PMID: 28336670 Free PMC article.

2016

P-selectin is a nanotherapeutic delivery target in the tumor microenvironment.

Shamay Y, Elkabets M, Li H, Shah J, Brook S, Wang F, Adler K, Baut E, Scaltriti M, Jena PV, Gardner EE, Poirier JT, Rudin CM, Baselga J, Haimovitz-Friedman A, Heller DA.Sci Transl Med. 2016 Jun 29;8(345):345ra87. doi: 10.1126/scitranslmed.aaf7374.PMID: 27358497 Free PMC article.

Streptococcus pneumoniae fructose-1,6-bisphosphate aldolase, a protein vaccine candidate, elicits Th1/Th2/Th17-type cytokine responses in mice.

Elhaik Goldman S, Dotan S, Talias A, Lilo A, Azriel S, Malka I, Portnoi M, Ohayon A, Kafka D, Ellis R, Elkabets M, Porgador A, Levin D, Azhari R, Swiatlo E, Ling E, Feldman G, Tal M, Dagan R, Mizrachi Nebenzahl Y.Int J Mol Med. 2016 Apr;37(4):1127-38. doi: 10.3892/ijmm.2016.2512. Epub 2016 Mar 1.PMID: 26935978

Molecular Pathways: AXL, a Membrane Receptor Mediator of Resistance to Therapy.

Scaltriti M, Elkabets M, Baselga J.Clin Cancer Res. 2016 Mar 15;22(6):1313-7. doi: 10.1158/1078-0432.CCR-15-1458. Epub 2016 Jan 13.PMID: 26763248 Free PMC article. Review.

2015

AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas.

Elkabets M, Pazarentzos E, Juric D, Sheng Q, Pelossof RA, Brook S, Benzaken AO, Rodon J, Morse N, Yan JJ, Liu M, Das R, Chen Y, Tam A, Wang H, Liang J, Gurski JM, Kerr DA, Rosell R, Teixidó C, Huang A, Ghossein RA, Rosen N, Bivona TG, Scaltriti M, Baselga J.Cancer Cell. 2015 Apr 13;27(4):533-46. doi: 10.1016/j.ccell.2015.03.010.PMID: 25873175 Free PMC article.

2014

Rationale-based therapeutic combinations with PI3K inhibitors in cancer treatment.

Castel P, Toska E, Zumsteg ZS, Carmona FJ, Elkabets M, Bosch A, Scaltriti M.Mol Cell Oncol. 2014 Oct 29;1(3):e963447. doi: 10.4161/23723548.2014.963447. eCollection 2014 Jul-Sep.PMID: 27308344 Free PMC article. Review.

Antagonism of EGFR and HER3 enhances the response to inhibitors of the PI3K-Akt pathway in triple-negative breast cancer.

Tao JJ, Castel P, Radosevic-Robin N, Elkabets M, Auricchio N, Aceto N, Weitsman G, Barber P, Vojnovic B, Ellis H, Morse N, Viola-Villegas NT, Bosch A, Juric D, Hazra S, Singh S, Kim P, Bergamaschi A, Maheswaran S, Ng T, Penault-Llorca F, Lewis JS, Carey LA, Perou CM, Baselga J, Scaltriti M.Sci Signal. 2014 Mar 25;7(318):ra29. doi: 10.1126/scisignal.2005125.PMID: 24667376 Free PMC article.

2013

mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PIK3CA-mutant breast cancer.

Elkabets M, Vora S, Juric D, Morse N, Mino-Kenudson M, Muranen T, Tao J, Campos AB, Rodon J, Ibrahim YH, Serra V, Rodrik-Outmezguine V, Hazra S, Singh S, Kim P, Quadt C, Liu M, Huang A, Rosen N, Engelman JA, Scaltriti M, Baselga J.Sci Transl Med. 2013 Jul 31;5(196):196ra99. doi: 10.1126/scitranslmed.3005747.PMID: 23903756 Free PMC article.

Unique Versus Redundant Functions of IL-1α and IL-1β in the Tumor Microenvironment.

Voronov E, Dotan S, Krelin Y, Song X, Elkabets M, Carmi Y, Rider P, Idan Cohen, Romzova M, Kaplanov I, Apte RN.Front Immunol. 2013 Jul 8;4:177. doi: 10.3389/fimmu.2013.00177. eCollection 2013.PMID: 23847618 Free PMC article.

2006-2012

The natural cytotoxicity receptor 1 contribution to early clearance of Streptococcus pneumoniae and to natural killer-macrophage cross talk.

Elhaik-Goldman S, Kafka D, Yossef R, Hadad U, Elkabets M, Vallon-Eberhard A, Hulihel L, Jung S, Ghadially H, Braiman A, Apte RN, Mandelboim O, Dagan R, Mizrachi-Nebenzahl Y, Porgador A.PLoS One. 2011;6(8):e23472. doi: 10.1371/journal.pone.0023472. Epub 2011 Aug 22.PMID: 21887255 Free PMC article.

Microenvironment-derived IL-1 and IL-17 interact in the control of lung metastasis.

Carmi Y, Rinott G, Dotan S, Elkabets M, Rider P, Voronov E, Apte RN.J Immunol. 2011 Mar 15;186(6):3462-71. doi: 10.4049/jimmunol.1002901. Epub 2011 Feb 7.PMID: 21300825 Free article.

Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice.

Elkabets M, Gifford AM, Scheel C, Nilsson B, Reinhardt F, Bray MA, Carpenter AE, Jirström K, Magnusson K, Ebert BL, Pontén F, Weinberg RA, McAllister SS.J Clin Invest. 2011 Feb;121(2):784-99. doi: 10.1172/JCI43757. Epub 2011 Jan 25.PMID: 21266779 Free PMC article.

IL-1β regulates a novel myeloid-derived suppressor cell subset that impairs NK cell development and function.

Elkabets M, Ribeiro VS, Dinarello CA, Ostrand-Rosenberg S, Di Santo JP, Apte RN, Vosshenrich CA.Eur J Immunol. 2010 Dec;40(12):3347-57. doi: 10.1002/eji.201041037.PMID: 21110318 Free PMC article.

Sialylation of 3-methylcholanthrene-induced fibrosarcoma determines antitumor immune responses during immunoediting.

Cohen M, Elkabets M, Perlmutter M, Porgador A, Voronov E, Apte RN, Lichtenstein RG.J Immunol. 2010 Nov 15;185(10):5869-78. doi: 10.4049/jimmunol.1001635. Epub 2010 Oct 18.PMID: 20956342 Free article.

Targeting of polymeric nanoparticles to lung metastases by surface-attachment of YIGSR peptide from laminin.

Sarfati G, Dvir T, Elkabets M, Apte RN, Cohen S.Biomaterials. 2011 Jan;32(1):152-61. doi: 10.1016/j.biomaterials.2010.09.014. Epub 2010 Oct 14.PMID: 20889205

IL-1-induced inflammation promotes development of leishmaniasis in susceptible BALB/c mice.

Voronov E, Dotan S, Gayvoronsky L, White RM, Cohen I, Krelin Y, Benchetrit F, Elkabets M, Huszar M, El-On J, Apte RN.Int Immunol. 2010 Apr;22(4):245-57. doi: 10.1093/intimm/dxq006. Epub 2010 Feb 24.PMID: 20181656

Differences in the sialylation patterns of membrane stress proteins in chemical carcinogen-induced tumors developed in BALB/c and IL-1alpha deficient mice.

Avidan A, Perlmutter M, Tal S, Oraki O, Kapp T, Krelin Y, Elkabets M, Dotan S, Apte RN, Lichtenstein RG.Glycoconj J. 2009 Dec;26(9):1181-95. doi: 10.1007/s10719-009-9238-9.PMID: 19430902

Host-derived interleukin-1alpha is important in determining the immunogenicity of 3-methylcholantrene tumor cells.

Elkabets M, Krelin Y, Dotan S, Cerwenka A, Porgador A, Lichtenstein RG, White MR, Zoller M, Iwakura Y, Dinarello CA, Voronov E, Apte RN.J Immunol. 2009 Apr 15;182(8):4874-81. doi: 10.4049/jimmunol.0803916.PMID: 19342666

Interleukin-1beta-driven inflammation promotes the development and invasiveness of chemical carcinogen-induced tumors.

Krelin Y, Voronov E, Dotan S, Elkabets M, Reich E, Fogel M, Huszar M, Iwakura Y, Segal S, Dinarello CA, Apte RN.Cancer Res. 2007 Feb 1;67(3):1062-71. doi: 10.1158/0008-5472.CAN-06-2956.PMID: 17283139

The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions.

Apte RN, Dotan S, Elkabets M, White MR, Reich E, Carmi Y, Song X, Dvozkin T, Krelin Y, Voronov E.Cancer Metastasis Rev. 2006 Sep;25(3):387-408. doi: 10.1007/s10555-006-9004-4.PMID: 17043764 Review.

Effects of micro-environment- and malignant cell-derived interleukin-1 in carcinogenesis, tumour invasiveness and tumour-host interactions.

Apte RN, Krelin Y, Song X, Dotan S, Recih E, Elkabets M, Carmi Y, Dvorkin T, White RM, Gayvoronsky L, Segal S, Voronov E.Eur J Cancer. 2006 Apr;42(6):751-9. doi: 10.1016/j.ejca.2006.01.010. Epub 2006 Mar 10.PMID: 16530403 Review.

Differential effects of monastrol in two human cell lines.

Leizerman I, Avunie-Masala R, Elkabets M, Fich A, Gheber L.Cell Mol Life Sci. 2004 Aug;61(16):2060-70. doi: 10.1007/s00018-004-4074-3.PMID: 15316655

Publications